The sesquiterpene (+)-zizaene is the direct precursor of khusimol, the main fragrant compound of the Skirt vetiver essential oil from Chrysopogon zizanioides and used in nearly 20% of men’s fine perfumery.The biotechnological production of such fragrant sesquiterpenes is a promising alternative towards sustainability; nevertheless, product re
PARPi-FL - a Fluorescent PARP1 Inhibitor for Glioblastoma Imaging
New intravital optical imaging technologies have revolutionized our understanding of mammalian biology PVC FREE DRYERBALLS and continue to evolve rapidly.However, there are only a limited number of imaging probes available to date.In this study, we investigated in mouse models of glioblastoma whether a fluorescent small molecule inhibitor of the DN
Physiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who DONG QUAI were treatedwith Lu-177 DOTATATE.The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole bo
Targeting molecular networks for drug research
The study of molecular networks has recently moved into the limelight of biomedical research.While it has certainly provided us with plenty of new insights into cellular mechanisms, the challenge now is how to modify or even restructure these networks.This is especially true for human diseases, which can be regarded as manifestations of distorted s